More than half of American adults and about 30% of American children report taking vitamins or other dietary supplements, fueling a $40 billion a year industry that the Food and Drug Administration (FDA) estimates has put 80,000 or more products on the market. Vitamin and mineral supplements are recommended by doctors for the elderly, pregnant women, and other populations at risk of specific nutrient deficiencies. However, there is little evidence that supplements benefit generally healthy people, and some studies have identified potential harms. Variations in how individuals absorb nutrients, and the routine addition of vitamins and minerals to several common foods, complicate assessments of supplements’ potential benefits and risks. Further, supplement manufacturers do not have to demonstrate safety or efficacy of their products, or get FDA approval for the claims, ingredient lists, or dosages on their labels, before they are marketed. All of these factors create a challenging environment for consumers to make informed decisions about their personal health.